Mine survived 800+ miles or so hard riding in Portugal, as did 4 others, without any special treatment from HD tubes or fiddling with the pressure.

For the Pyrenees, normal tubes, at normal pressures will be fine.

The sidewall of the TKC was goosed by the end but not a single pinch puncture in 4000 miles (thats 5 bikes covering 800 miles), and we were riding some of the rocky stuff very fast...... I think I recal 70mph indicated during one 'spirited' section of track..... and a 40mph climb on large rocks (the size of footballs some of them).

I do run HD tubes in the TTR but then it does have to contend with some very muddy/boggy environments at times, so reducing the pressure does help. But I never suffered any issues with normal tubes either.

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Never underestimate the power of stupid people in large groups.